RISK STRATIFICATION OF SUDDEN CARDIAC DEATH IN HYPERTROPHIC CARDIOMYOPATHY

Sudden cardiac death risk in hypertrophic cardiomyopathy.

It is well recognized that sudden cardiac death (SCD) is an infrequent, unpredictable, but catastrophic complication of hypertrophic cardiomyopathy (HCM). In population-based studies the overall SCD rate is 1% per year among patients with a clinical diagnosis of HCM. A crucial aspect of the management of patients with HCM is an assessment of each individual patient’s risk for SCD so that preven...

Risk stratification and prevention of sudden death in hypertrophic cardiomyopathy.

Sudden unexpected death, often occurring in young, asymptomatic patients, is the most devastating facet of the natural history of hypertrophic cardiomyopathy, and appears to be the consequence of primary ventricular tachyarrhythmias arising in an electrically unstable myocardial substrate characterized by disorganized cellular architecture, ischemia, cell death, and replacement scarring. Althou...

Hypertrophic cardiomyopathy: management, risk stratification, and prevention of sudden death.

http://heart.bmj.com/cgi/content/full/87/2/169 Updated information and services can be found at: These include: Data supplement http://heart.bmj.com/cgi/content/full/87/2/169/DC1 "Web only references" References http://heart.bmj.com/cgi/content/full/87/2/169#otherarticles 16 online articles that cite this article can be accessed at: http://heart.bmj.com/cgi/content/full/87/2/169#BIBL This artic...

Importance of sudden cardiac death risk stratification in hypertrophic cardiomyopathy. Response.

Late gadolinium enhancement cardiovascular magnetic resonance for sudden cardiac death risk stratification in hypertrophic cardiomyopathy

Background Although myocardial fibrosis identified by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) may predict adverse outcomes among patients with hypertrophic cardiomyopathy (HCM), its precise role in risk stratification for sudden cardiac death (SCD) remains unresolved. Previous studies have relied on broad surrogate composite endpoints and were underpowered to a...